LymphedemaV1, Main, Exploration, bibRecord, 00DA37

Differential recognition of Brugia malayi antigens by bancroftian filariasis sera.

Identifieur interne : 00DA37 ( Main/Exploration ); précédent : 00DA36; suivant : 00DA38

Differential recognition of Brugia malayi antigens by bancroftian filariasis sera.

Auteurs : P B Parab ; G R Rajasekariah ; P A Carvalho ; D. Subrahmanyam

Source :

The Indian journal of medical research [ 0971-5916 ] ; 1990.

RBID : pubmed:2188906

Descripteurs français

KwdFr :
- Animaux, Anticorps antihelminthe (immunologie), Antigènes d'helminthe (immunologie), Brugia (immunologie), Cytotoxicité à médiation cellulaire dépendante des anticorps, Filariose lymphatique (immunologie), Filarioses (immunologie), Humains, Immunotransfert, Wuchereria (immunologie), Wuchereria bancrofti (immunologie).
MESH :
- immunologie : Anticorps antihelminthe, Antigènes d'helminthe, Brugia, Filariose lymphatique, Filarioses, Wuchereria, Wuchereria bancrofti.
- Animaux, Cytotoxicité à médiation cellulaire dépendante des anticorps, Humains, Immunotransfert.

English descriptors

KwdEn :
- Animals, Antibodies, Helminth (immunology), Antibody-Dependent Cell Cytotoxicity, Antigens, Helminth (immunology), Brugia (immunology), Elephantiasis, Filarial (immunology), Filariasis (immunology), Humans, Immunoblotting, Wuchereria (immunology), Wuchereria bancrofti (immunology).
MESH :
- chemical , immunology : Antibodies, Helminth, Antigens, Helminth.
- immunology : Brugia, Elephantiasis, Filarial, Filariasis, Wuchereria, Wuchereria bancrofti.
- Animals, Antibody-Dependent Cell Cytotoxicity, Humans, Immunoblotting.

Abstract

Individuals residing in an area endemic to Wuchereria bancrofti infection were broadly categorised as endemic normals (EN), microfilaraemics (mf + ve) and elephantoids i.e., chronic lymphatic filariasis (EL). The immune status of these three groups was examined in terms of (i) specific antibody levels; (ii) ability to induce antibody dependent cellular cytotoxicity (ADCC) to microfilariae; and (iii) ability to recognise different microfilarial antigens by immunoblotting. All three groups of endemic residents were indistinguishable in their antibody levels as measured by ELISA with B. malayi microfilarial antigen. Many endemic normal sera and most elephantoid sera exerted strong cytotoxicity against W. bancrofti microfilariae whereas none of the mf + ve sera had any such activity. Immunoblotting studies revealed that a protein with mol. wt of 79 KDa was the only one among the proteins of B. malayi microfilarial extracts that was consistently recognised by sera from all endemic residents. Endemic normal sera and elephantoid sera, which exerted maximum cytotoxicity, together specifically recognised three proteins with molecular weights 25, 58 and 68 KDa and these three proteins could be among the candidate antigens that induce resistance to filarial infection.

PubMed: 2188906

Affiliations:

Le document en format XML

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<term>Brugia (immunology)</term>
<term>Elephantiasis, Filarial (immunology)</term>
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<term>Brugia (immunologie)</term>
<term>Cytotoxicité à médiation cellulaire dépendante des anticorps</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Filarioses (immunologie)</term>
<term>Humains</term>
<term>Immunotransfert</term>
<term>Wuchereria (immunologie)</term>
<term>Wuchereria bancrofti (immunologie)</term>
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<term>Filarioses</term>
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<term>Wuchereria bancrofti</term>
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<front><div type="abstract" xml:lang="en">Individuals residing in an area endemic to Wuchereria bancrofti infection were broadly categorised as endemic normals (EN), microfilaraemics (mf + ve) and elephantoids i.e., chronic lymphatic filariasis (EL). The immune status of these three groups was examined in terms of (i) specific antibody levels; (ii) ability to induce antibody dependent cellular cytotoxicity (ADCC) to microfilariae; and (iii) ability to recognise different microfilarial antigens by immunoblotting. All three groups of endemic residents were indistinguishable in their antibody levels as measured by ELISA with B. malayi microfilarial antigen. Many endemic normal sera and most elephantoid sera exerted strong cytotoxicity against W. bancrofti microfilariae whereas none of the mf + ve sera had any such activity. Immunoblotting studies revealed that a protein with mol. wt of 79 KDa was the only one among the proteins of B. malayi microfilarial extracts that was consistently recognised by sera from all endemic residents. Endemic normal sera and elephantoid sera, which exerted maximum cytotoxicity, together specifically recognised three proteins with molecular weights 25, 58 and 68 KDa and these three proteins could be among the candidate antigens that induce resistance to filarial infection.</div>
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Serveur d'exploration sur le lymphœdème

Differential recognition of Brugia malayi antigens by bancroftian filariasis sera.

Differential recognition of Brugia malayi antigens by bancroftian filariasis sera.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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